Michael Hallek Selected Research

Cytokines

10/2023	LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1.
1/2022	Rapid Manufacturing of Highly Cytotoxic Clinical-Grade SARS-CoV-2-specific T Cell Products Covering SARS-CoV-2 and Its Variants for Adoptive T Cell Therapy.
9/2020	Relevant Cytokines in the B Cell Lymphoma Micro-Environment.
12/2014	Impact of exercise on pro inflammatory cytokine levels and epigenetic modulations of tumor-competitive lymphocytes in Non-Hodgkin-Lymphoma patients-randomized controlled trial.
11/2014	Inhibition of protein geranylgeranylation specifically interferes with CD40-dependent B cell activation, resulting in a reduced capacity to induce T cell immunity.
1/2014	Sensitizing protective tumor microenvironments to antibody-mediated therapy.
2/2013	mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice.
9/2003	Vaccination against B-cell chronic lymphocytic leukemia with trioma cells: preclinical evaluation.

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Michael Hallek Research Topics

Disease

153	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 05/2024 - 01/2002
109	Neoplasms (Cancer) 04/2024 - 08/2002
25	Infections 05/2024 - 09/2002
24	Lymphoma (Lymphomas) 04/2024 - 08/2002
19	Residual Neoplasm 05/2023 - 01/2002
18	Disease Progression 05/2023 - 02/2006
17	Leukemia 01/2022 - 08/2002
11	Neutropenia 01/2022 - 05/2011
9	B-Cell Lymphoma (Lymphoma, B Cell) 02/2024 - 01/2013
9	COVID-19 10/2022 - 01/2020
8	Hodgkin Disease (Hodgkin's Disease) 08/2022 - 02/2008
8	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2019 - 08/2006
7	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2019 - 03/2009
6	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 04/2024 - 05/2007
6	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 02/2024 - 01/2012
6	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2023 - 12/2014
6	Hematologic Neoplasms (Hematological Malignancy) 01/2022 - 08/2010
6	Fatigue 01/2022 - 05/2007
5	Inflammation (Inflammations) 01/2023 - 04/2009
5	Fever (Fevers) 01/2021 - 11/2002
5	Lung Neoplasms (Lung Cancer) 01/2020 - 06/2010
4	Chromosome Aberrations (Chromosome Abnormalities) 01/2023 - 09/2002
4	Multiple Myeloma 01/2021 - 03/2006
4	Carcinoma (Carcinomatosis) 10/2018 - 01/2005
3	Glioblastoma (Glioblastoma Multiforme) 01/2023 - 09/2020
3	Tumor Lysis Syndrome 05/2022 - 01/2020
3	T-Cell Prolymphocytic Leukemia (Leukemia, T Cell, Chronic) 01/2022 - 06/2013
3	Pneumonia (Pneumonitis) 01/2022 - 01/2012
3	Hemorrhage 01/2022 - 11/2002
3	Thrombocytopenia (Thrombopenia) 01/2022 - 11/2002
3	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2021 - 05/2004
3	Melanoma (Melanoma, Malignant) 01/2020 - 01/2016
3	Pathologic Complete Response 02/2017 - 11/2007
3	Carcinogenesis 10/2015 - 01/2013
3	Body Weight (Weight, Body) 01/2011 - 10/2009
2	Hematologic Diseases (Blood Diseases) 08/2023 - 06/2014
2	Prolymphocytic Leukemia 04/2023 - 05/2015

Drug/Important Bio-Agent (IBA)

45	Rituximab (Mabthera)FDA Link 05/2024 - 11/2002
36	fludarabineIBA 05/2024 - 06/2002
29	Cyclophosphamide (Cytoxan)FDA LinkGeneric 05/2024 - 09/2005
28	venetoclaxIBA 04/2024 - 06/2016
24	obinutuzumabIBA 04/2024 - 03/2014
24	ibrutinibIBA 02/2024 - 01/2015
17	Bendamustine Hydrochloride FDA Link 04/2024 - 09/2011
15	Proteins (Proteins, Gene)FDA Link 01/2023 - 09/2005
14	Alemtuzumab (Campath)FDA Link 03/2017 - 01/2002
13	AntigensIBA 10/2022 - 08/2002
12	LigandsIBA 01/2021 - 03/2006
10	idelalisibIBA 04/2024 - 03/2014
10	Biomarkers (Surrogate Marker)IBA 11/2023 - 03/2005
10	AntibodiesIBA 05/2023 - 08/2002
10	Monoclonal AntibodiesIBA 01/2022 - 08/2002
9	Chlorambucil (Leukeran)FDA Link 10/2023 - 10/2009
9	Phosphotransferases (Kinase)IBA 12/2020 - 05/2004
8	CytokinesIBA 10/2023 - 09/2003
8	Agammaglobulinaemia Tyrosine KinaseIBA 01/2022 - 01/2015
6	CD40 Ligand (CD40L)IBA 11/2012 - 09/2002
5	DNA (Deoxyribonucleic Acid)IBA 11/2023 - 07/2011
5	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 01/2007
5	Lenalidomide (CC 5013)FDA Link 01/2021 - 03/2012
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2020 - 07/2010
4	VaccinesIBA 10/2022 - 10/2008
4	Doxorubicin (Adriamycin)FDA LinkGeneric 02/2022 - 02/2015
4	Immunoglobulins (Immunoglobulin)IBA 11/2021 - 09/2003
4	Interleukin-6 (Interleukin 6)IBA 09/2020 - 02/2013
4	Thymidine KinaseIBA 01/2020 - 03/2005
4	ErbB Receptors (EGF Receptor)IBA 10/2019 - 12/2010
3	Cytarabine (Cytosar-U)FDA LinkGeneric 04/2024 - 08/2016
3	Protein Isoforms (Isoforms)IBA 01/2023 - 11/2015
3	Histones (Histone)IBA 01/2023 - 08/2014
3	RNA (Ribonucleic Acid)IBA 10/2022 - 04/2011
3	Vincristine (Oncovin)FDA LinkGeneric 02/2022 - 02/2015
3	Prednisone (Sone)FDA LinkGeneric 02/2022 - 02/2015
3	MicroRNAs (MicroRNA)IBA 01/2022 - 10/2009
3	Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)IBA 01/2022 - 04/2011
3	Antiviral Agents (Antivirals)IBA 01/2022 - 01/2022
3	Brentuximab VedotinIBA 01/2021 - 02/2013
3	Macrophage Migration-Inhibitory FactorsIBA 01/2017 - 04/2009
3	HLA Antigens (Human Leukocyte Antigens)IBA 12/2012 - 08/2002
3	src-Family KinasesIBA 08/2008 - 01/2003
3	enhanced green fluorescent proteinIBA 12/2006 - 09/2002
2	Dexamethasone (Maxidex)FDA LinkGeneric 04/2024 - 08/2016
2	Bortezomib (Velcade)FDA Link 04/2024 - 01/2012
2	Everolimus FDA Link 04/2024 - 02/2013
2	Chimeric Antigen ReceptorsIBA 02/2024 - 01/2012
2	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2023 - 01/2004
2	GlucocorticoidsIBA 12/2023 - 09/2005
2	Circulating Tumor DNAIBA 11/2023 - 01/2020
2	AnthracyclinesIBA 01/2023 - 11/2002

Therapy/Procedure

75	Therapeutics 04/2024 - 06/2002
36	Drug Therapy (Chemotherapy) 12/2023 - 08/2006
17	Stem Cell Transplantation 01/2023 - 01/2002
11	Hematopoietic Stem Cell Transplantation 01/2019 - 08/2010
10	Immunotherapy 10/2022 - 01/2005
8	Transplantation 01/2023 - 01/2011
5	Palliative Care (Palliative Therapy) 11/2019 - 05/2008
4	Radiotherapy 01/2021 - 07/2008
4	Aftercare (After-Treatment) 01/2021 - 02/2015
2	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation) 04/2024 - 02/2012
2	Precision Medicine 08/2023 - 04/2016